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Stop Smoking > Pharmacokinetics
The following information is about Pharmacokinetics.
Pharmacokinetics Defined
The pattern of absorption, distribution, metabolism, and elimination of a drug over time.
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Off-site Pharmacokinetics Links, User Submitted
The following links have been collected through user bookmark submission in the Pharmacokinetics category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.
Sun Aug 24
- Clinically relevant pharmacokineti c drug interactions with second-generat ion antidepressant s: An update. [Clin Ther. 2008 Jul;30(7):1206 -27.]: Second-generat ion antidepressant s differ in their potential for pharmacokineti c drug interactions. Fluoxetine and paroxetine are potent inhibitors of CYP2D6, fluvoxamine markedly inhibits CYP1A2 and CYP2C19, and nefazodone is a substantial inhibitor of CYP3A4. Therefore, clinically relevant interactions may be expected when these antidepressant s are coadministered with substrates of the pertinent isozymes, particularly those with a narrow therapeutic index. Duloxetine and bupropion are moderate inhibitors of CYP2D6, and sertraline may cause significant inhibition of this isoform, but only at high doses. Citalopram, escitalopram, venlafaxine, mirtazapine, and reboxetine are weak or negligible inhibitors of CYP isozymes in vitro and are less likely than other second-generat ion antidepressant s to interact with co-administere d medications.
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- Guidance Documents - Applications and Submissions - Drug Products
- The big Pharma lobby - Re: Vitamin C Injections Slow Tumor Growth In Mice - sci.med.nutrit ion | Google Groups: Decent collection of references on vitamin c pharmacokineti cs
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